Peptide and Protein Chemistry

The goal of this course is to explore how chemical methods and concepts have impacted our ability to understand and manipulate protein structure and function. We will navigate this subject through a combination of lectures and structured discussions on research articles from the literature. The course is divided into three segments: (1) In the first part, we will review the rudiments of protein structure and function, then delve into various aspects of enzyme chemistry and polypeptide biosynthesis. (2) In the second part of the course, we will cover synthetic methods to produce and chemically modify peptides and proteins. (3) In the final part, we will discuss chemical approaches to control protein function and monitor protein activity, focusing on methods that use small molecules and mass spectrometry proteomics.